Testosterone Replacement Therapy (TRT) is a prescription medical treatment requiring evaluation and ongoing supervision by a licensed healthcare provider. Treatment is prescribed only after a comprehensive medical review, including laboratory testing and assessment of contraindications. Possible risks include changes in blood pressure, changes in red blood cell count (hematocrit), changes in cholesterol, mood changes, acne, fluid retention, sleep apnea, and effects on fertility. Liver function should be monitored. Patients with a history of prostate or breast cancer, uncontrolled cardiovascular disease, severe liver or kidney disease, untreated sleep apnea, or elevated hematocrit may not be candidates for therapy. Individual results vary and no specific outcome is guaranteed. This content is for informational purposes only, does not constitute medical advice, and has been physician-reviewed prior to publication.